As @NJDave71 is no longer creating No Nags for Mame, here are 2 replacements.
mame64.exe - Normal Mame with Nags removed.
arcademame64.exe - This is a slimmed down version of Mame to just cover Arcade only (please note it only covers Arcade)
Its recommended to download the full 0.218 official pack and install it, then just overwrite the exe with the replacment, this covers any changes the mame devs may have made to the suppot files.
After you have done this, make sure you copy the folders artwork, ctrlr, cheat, hlsl, ini, folders and the mame.ini file from your original mame folder, and move/copy them to the new install.
Tnx to KnC for this.