I have a Retroid Pocket 4 Pro that hasn't had any issues (Android 13, MTK D1100, 8GB RAM).
However, I just recently got my partner a Retroid Pocket 2S (Android 11, Unisoc T610, 4GB RAM) that's been having strange issues with Launchbox seemingly whenever it tries to write the XML files (when downloading media for games, setting favorites, etc). Launchbox isn't crashing, but instead seems to just freeze. I have to force-close the app, wait a second, and then re-open it before it will work properly... and then any changes I made will be reverted (likely due to the way the whole XML backup transaction bits work... not sure, just guessing).
They are both setup to use internal storage for LaunchBox, and only use microSD cards for the actual ROM files.
Have you seen or heard of this behavior before, @faeran?