I figured out in my settings that the conflict with my 5 screens was Retroarch then on Video > Output > Monitor Index > choose the monitor number and that fixed the whole problem, even MAME that was acting weird as well!
That's for the Bigbox engine only, I'm having a problem with Third Screen plugin, after setting everything to my liking now my games are running on the fifth screen and can't find how to make my screen 1 primary for all emulation! 😓