Thank you so much for taking the time to try and help me!!! Here are the answers to your questions:
LaunchBox Version: 13.22
Big Box Theme: StationEmulation
Theme Version: 1.4
Where I Got the Theme: I believe I just downloaded it from the "Available - All" area from Manage Themes in the System Menu.
Video Playback Engine: VLC (deprecated)
Running anything in Big Box when it happens: Nope; I am not using Attract Mode or Screen Savers
Big Box Section that I am leaving it in when it happens: Not any one specific section; I don't have the system menu or anything like that open. It's just at the user level where you can select games or systems.
Does my computer go to sleep or monitors turn off after a certain time: Nope, I am using a TV rather than a monitor. And I have the settings all set to "Never" for for hibernating, sleeping, and turning off my screen.
Any power options that turn off pieces of my computer, like USB ports, network, hard drives, etc.?: I went to Device Manager and checked my USB ports, network card, and HID devices. I did see that a few of them were set to "Allow the computer the computer to turn off this device to save power". I feel like I have already configured this option before, but I went and unchecked that option again anyways. It's certainly possible I have missed it with all the configurations I've made. I'll report back within a week to see if that was culprit.
In the mean time, based on the information I've given, is there anything else I should be checking, updating, or doing? Thank you again for your help!