When you emulate games like Super Mario Galaxy and Sonic Colors, sometimes you need a especific/diferent Build/configuration. But in Launchbox, you can't use more than one emulator in the category (like Gamecube).
Ex: you used build 4.0.2, but had a game who only works in an especific build, like 3.0.
In Adv Launcher, used in Kodi/XBMC, you can clickin the menu context (C button), choose advanced modifications and choose alternative aplication to the rom/iso.