Maybe I'm not phrasing it correctly. When I add a platform, I don't use the UI to change the 34 folder paths found in Edit Platform. I feel it simply takes far too long and is too prone to error since I have to do each one manually. What I do instead is import all the platforms I'm planning to do, let it pull in all the images and whatnot it wants, and when that's done I close LB. I go into the LB install folder and copy the Images, Music, Manuals, and Videos folders to my media folder on my larger storage drive and I used Notepad++ to do a find and replace in Platforms XML to change the XML from <FolderPath>Images\Saturn\Box - Front</FolderPath> to <FolderPath>E:\Launchbox Meta\Images\Saturn\Box - Front</FolderPath>, only I'm doing a Replace All going from ">Images\" to ">E:\Launchbox Meta\Images\". And I repeat for Videos, Music, and Manuals. This gets the platform setup and the files where I want them faster than manually editing 34 fields through the UI. I edit the Games path via the UI as my platform naming isn't consistent with Launchbox's and I've never bothered to change it.
In the past, this process worked fine, I'd reopen LB and the images would all still work but if I edited a platform, I could see the folder paths had been updated to reflect my changes in the XML. This time, however, the changes were not reflected and it appears the XML was cached or restored from a backup.
Although I kept changing the file back and closing/opening LB and now my changes are in so...not sure what was going on, but it seems fine now. Maybe Notepad++ was locking the file or I typo'd a path in the replace.