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I had this same problem--neither Mednafen or Yabause will open a cue with multiple tracks in Retroarch. Mednafen crashes and Yabause only works if you load the BIN or ISO directly (ignore the cue), but in the latter case the audio tracks are not loaded and there is no music in the game. This can be fixed by redumping the multi-track CD image into a single bin/iso and cue file. This is pretty easy. Here is a guide: https://maguslogs.blogspot.com/2016/09/howto-convert-ps1-games-with-multiple-tracks-to-one-bin-and-cue.html After re-dumping my multi-track images into single cue/iso images, almost everything works for me in both Mednafen and Yabause.