This is the 2nd installation i guess you could say... When I initially installed Launchbox it was setup on my C drive then I moved everything over to its own separate drive... But here is the thing if i go into bigbox mode and select that same PS2 file it does the same exact thing.
Edit: Not sure if this is of any help but i opened task manager to monitor while clicking on a Genesis game it comes up "suspended" under status then proceeds to close itself. Also went and started closing programs 1 by 1 razer synapse,Corsair iCue, Aorus software etc problem still persists... Removed entire Genesis playlist and re-downloaded all artwork for the playlist still same issue... I cannot figure this out... I may test on a secondary PC to see if issue happens there using the same ROM files.