Windows 10, using Defender and Malware Bytes as security software. I do have Google Drive in use, but nothing in it relates in any way to Launchbox, its data, or any games.
An update to my earlier post: I wrote it before I downloaded and updated to v12.14. When I did download the update, I got a warning in Firefox that the file might harm my computer with an option to keep or discard it. I kept it, and ran it. After running the install (I run the program from my D:\Launchbox folder), I got the same "trouble starting the setup" warning when I tried to run LB. However, after I dismissed the warning, LB ran just fine and was fully updated. Could Defender or Malwarebytes be interfering?