Hi all, I don't belong to the LaunchBox community per se, but I had the same audio issue using Daphne and came here to find a resolution. I didn't find one here, but once I figured it out, I had to post back here for the simplest solution that we all overlooked. Assuming that you're still using Daphne.exe and Windows 10, what you do is right click the Daphne.exe, goto properties, goto compatibility, hit the button that says "change high DPI settings", put a check in "High DPI scaling override" near the bottom, and on the drop down menu there, choose "Application". Apply that bad boy and now you can use 1650x1050 or whatever and you will have fullscreen plus sound. I'm also using OpenGL within Daphne...not sure that even matters, but there you are.