I had this problem and this is what worked for me, because the autoskip feature in the MameUI program was no working for me, if you are using mameUI, go to the MameUi folder and go to the INI Folder, there should be a list of .ini files for every game youve played so far on mame, minimize that window and bring up launchbox and start the game thats giving you issues, once the game loads type f11 then hit f9, keep pressing f9 untill you see the game is running at 100% there should be a number in the corner that will increase untill it hits 100% keep a mental note of the number of time you hit f9. Now bring up your MameUI INI folder again go into the game and scroll down the .ini file untill you see a line that says frameskip, enter the number for the times you hit f9 previously, save the file. That should fix it, the only problem is you will have to repeat this process whenevr you encounter the issue again with a different game.