At first glance, the MiSTer integration seems awesome, but I'm wondering what the practicality would be. When I'm using Launchbox/BigBox, I'm typically connected to the same TV that my MiSTer is connected to, so it would be strange to launch a game from Launchbox and then switch to another TV input to play the game on MiSTer. Why not just switch to MiSTer and launch it there? Perhaps it might be quicker to find the game through Launchbox, but you still need need to spend time switching inputs.
I do currently use an Android app called Tatsutron that does something similar, albeit through an Android app. This makes more sense to me, launching a game from a cell phone and seeing the results immediately on your TV, but in actuality, I still find myself not using the app much. It's easier to just launch things through the MiSTer.
Am I missing a use case? I hope so!