Mike,
I did not have to set up much of anything, this has launchbox, Big Box all the emulators and roms. go here:
Go to the bottom of the list and you will find: CP78.All.Hits.No Shit.LB.Edition- CP78 , along with updates 1.01-1.07, these add fixes and additional systems to the original download.
It is a much easier route than trying to configure all the emulators yourself. That's what I did anyway.
Everett