I'm glad to see there are others crazy people like me
My collection is way short than yours, but I've spend a lot of time on it mainly because of the epuration of clones and the naming / illustrating part.
By now it's about 21 300 games, but I've rename them all and find the most covers by myself (or even create for the hacks)
However, i got all the clones on my disk, in case I want to play some specific, but they're not inside the launchbox collection
I totally agree about the region titles challenge