Windows 10, using Defender and Malware Bytes as security software.  I do have Google Drive in use, but nothing in it relates in any way to Launchbox, its data, or any games.
 
	An update to my earlier post:  I wrote it before I downloaded and updated to v12.14.  When I did download the update, I got a warning in Firefox that the file might harm my computer with an option to keep or discard it.  I kept it, and ran it.  After running the install (I run the program from my D:\Launchbox folder), I got the same "trouble starting the setup" warning when I tried to run LB.  However, after I dismissed the warning, LB ran just fine and was fully updated.  Could Defender or Malwarebytes be interfering?