OK. I know I'm going to get a load of people telling me this isn't happening but it definitely is.
It began with BigBox, every time I closed it, my wireless mouse wouldn't work and I had to unplug and reattach the USB receiver to get it going again.
However, since yesterday when Launchbox is open, I get periodic (every 20mins or so) User Account Control requests to open a particular program (it was MusicBee, to the point I uninstalled it, now it's another program). Also, my mouse is randomly stopping and my (wireless Logitech) keyboard acts as though the ctrl button is pressed (this is solved by ctrl+alt+del and simply exiting again), but these things ONLY HAPPEN while Launchbox is open.
I can provide any more info you need, but this is very irritating as it happens while I am running emulators too.