It looks like somehow LaunchBox was installed into the wrong folder. If you look at the folder path, it looks like it was installed inside of your Plugins folder for some reason? Instead of installing it to E:\LaunchBox, it looks like it got installed to E:\LaunchBox\Plugins\LaunchBox. I'm not sure if that's the whole issue here (it probably could be), or if this just happened with the new version. You'll probably want to delete the E:\LaunchBox\Plugins\LaunchBox folder (assuming that's not where all your data and media is), and then reinstall to the E:\LaunchBox folder.
Also, what messages are you receiving from Windows about it being dangerous? Can you give me screenshots or the text of those messages?