You cannot directly emulate standard Xbox Live Indie Games (XBLIG) on a PC using mainstream Xbox 360 emulators like Xenia because XBLIG titles were built on Microsoft's XNA / .NET framework, which relies on managed intermediate language code that standard emulators do not fully implement yet. [1, 2]
However, you can still play or access these classic indie titles using alternative avenues.
Official PC Ports and Developer Releases
Check Developer Websites: Many original XBLIG developers released direct Windows ports of their indie games on platforms like Itch.io or their own sites (such as Bit Kid's anniversary releases).
Community Archives: Large historical dumps of the XBLIG library exist in community preservation spaces on Internet Archive, though running them typically requires tracking down individual community-made conversion patches or waiting for future updates to specialized recompilation project