thanks joe, this is driving me nuts...  taken from your coaching, this code in the tester WORKS, i see the circles pointing out where the mouse is.  when i change {Ctrl} to {LButton}, the mouse moves to the coordinates but it does not click.  second bit below, is the copy / paste of the LButton code so you can see i'm not crazy   and the bit at the very end, is cut and pasted from the full script.  tit opens both apps, doesn't move the mouse or hit CTRL.
 
	 
 
	anyway, you've spent way too much time on this, thanks for your time.
 
	DllCall("SetCursorPos", int, 1367, int, 820) 
	Send, {Ctrl}
 
	 
 
	DllCall("SetCursorPos", int, 1367, int, 820) 
	Send, {LButton}
 
	 
 
	; Start Virtual Desktop Streamer 
	Run, "C:\Program Files\Virtual Desktop Streamer\VirtualDesktop.Streamer.exe"
 
	; Start PrismXR application 
	Run, "C:\Users\tonys\Desktop\VR\PrismXR_Desktop_App\PrismXR\PrismXR.exe" 
	Sleep, 5000
 
	; move mouse pointer to center of monitor (1920x1080) 
	DllCall("SetCursorPos", int, 1367, int, 820) 
	Send, {Ctrl}