Zombeaver,
I've run into something that has me stumped and wondered if you'd encountered it before? When playing MULE with two players, the game recognizes one or both X-box controllers as keyboard at times. When reloading from a saved state, sometimes one or both of the controllers don't work. I think what's happening is that when the computer shuts down, then starts up later, the game is recognizing the controllers as different joysticks or keyboard inputs and the saved state doesn't match the current inputs.
Have you seen this before? Do you know of a way to change what inputs are assigned (joystick/keyboard)