It's happening for me, too. I got the notification to update yesterday, but I dismissed it and played a game. Later, I tried to open LaunchBox, and it automatically started updating. But, it never opened. I tried to start it again, and still nothing. I tried rebooting, updating my Geforce drivers, updating Windows, but still nothing.
Windows 10 Pro 64-bit
portable LaunchBox in my Google Drive folder
***edit***
I just tried installing to a different hard drive, and it works fine. Still can't get my original install to work, though.