I'm having the same issue using Cemu 1.6.3
If I start Cemu directly and than load the game, works fine.
If I start the game from the command line using
Cemu.exe -g "C:\WUP-P-ARDE\data\code\RedCarpet.rpx"
the game loads and starts fine also.
Whenever I use Launchbox (with or without the -g command option), I get the "Unable to open file" error from Cemu.
Any suggestions?
Edit: Reverted to Cemu 1.6.1 to see if it was related to the Optimized file operations + AES-NI support in version 1.6.2, but same error.