That system is bangin, of course, so any slowness you're running into is either a glitch that is specific to your system that we haven't found yet, or some kind of misconfiguration. If you can zip up and PM me your LaunchBox\Data folder, I'll take a look to see if it happens to be data-related. You shouldn't have to turn stuff off every time you run Big Box, of course, but I dare say that some anti-virus programs are absolute crap and can make even amazing systems crawl (especially if you happen to be running three of them).
Regardless, I'm more than happy to offer you a refund if you'd rather not try and figure it out, but I don't think it's possible for a system that fast to have performance issues in Big Box unless there's an anomaly going on.