Had this same issue and finally got it sorted out. Open Launch Box then right click on a Saturn Game and choose edit. Then under the launcher tab check to see which rom file the launcher is pointed to. In my case each game was pointing to "gamename (Track 01).bin" instead of "gamename".cue Changing this to point to the games .cue file fixed the issue. Also of note I was able to run all of the games through Retroarch using the Beetle/Mednafen Core. It was only when I attempted to run them in LaunchBox that I received the Drive Empty Message. And that was with the mednafen_saturn_libretro.dll core selected for Sega Saturn under Associated Platform.