For people who have a difficult time with Retroarchs "ribbon" UI you may want to check out this alternative called SkeletonKey. Some screenshots on the website to get a look at it. I did test it out briefly and I will just say this about it, it's not better or worse, just different. Retroarch is still a complex program with many options and settings and can be overwhelming.
Simply install the program wherever you want on your PC and point it to your Retroarch install if you have it installed already or you can have it download the necessary files for you.
http://romjacket.mudlord.info/SKELETONKEY/