No i dont experience those issues personally, except maybe if Windows is updating or something like that. I actually only have a 250GB ssd, on which i have windows, Launchbox and steam (allthough i install my steam games to other hdd's on my system). I have about 19000 games in my launchbox setup with all the images and videos for most of those games as well and my launchbox folder is currently about 138GB in size, but because all the relevant images and videos are on the ssd its smooth as butter, and just loads my roms from the usb drive.